GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs10461617 | 1 | rs2432195 | chr5:56120413 | C5orf35 | chr5:56205103-56213010:+ | 0.73 | 11.13 | 4.15E-25 | Type 2 diabetes |
| BLCA | cis | rs2251844 | 1 | rs2447196 | chr15:43893818 | ADAL | chr15:43622872-43646094:+ | 0.35 | 4.15 | 4.18E-5 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs2447196 | chr15:43893818 | CATSPER2 | chr15:43922774-43959900:- | 0.33 | 4.98 | 9.51E-7 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs2447208 | chr15:43933895 | ADAL | chr15:43622872-43646094:+ | -0.38 | -4.4 | 1.42E-5 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs2447208 | chr15:43933895 | CATSPER2 | chr15:43922774-43959900:- | -0.37 | -5.58 | 4.47E-8 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs2447208 | chr15:43933895 | CKMT1A | chr15:43985084-43991419:+ | -0.34 | -3.95 | 9.25E-5 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs2447211 | chr15:43936351 | ADAL | chr15:43622872-43646094:+ | -0.39 | -4.43 | 1.23E-5 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs2447211 | chr15:43936351 | CATSPER2 | chr15:43922774-43959900:- | -0.36 | -5.27 | 2.33E-7 | Tumor biomarkers |
| BLCA | cis | rs9369898 | 1 | rs2448704 | chr6:49453672 | CENPQ | chr6:49431096-49460820:+ | 0.41 | 8.85 | 3.37E-17 | Homocysteine levels |
| BLCA | cis | rs9473555 | 1 | rs2448707 | chr6:49446951 | CENPQ | chr6:49431096-49460820:+ | 0.28 | 5.56 | 4.93E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs2448707 | chr6:49446951 | MUT | chr6:49398994-49431031:- | -0.28 | -5.5 | 6.93E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs2243480 | 1 | rs2460422 | chr7:65601505 | CCT6P1 | chr7:65216092-65228661:+ | 0.33 | 4.56 | 6.79E-6 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs2462569 | chr7:65474846 | CCT6P1 | chr7:65216092-65228661:+ | -0.3 | -4.28 | 2.37E-5 | Diabetic kidney disease |
| BLCA | cis | rs30187 | 1 | rs246454 | chr5:96123264 | ERAP1 | chr5:96096515-96149837:- | -0.51 | -10.9 | 2.87E-24 | Ankylosing spondylitis |
| BLCA | cis | rs30187 | 1 | rs246454 | chr5:96123264 | ERAP2 | chr5:96211644-96255398:+ | 0.33 | 5.45 | 9.03E-8 | Ankylosing spondylitis |